|
|
(+)-bornyl-diphosphate + H2O <=> (+)-borneol + diphosphate
|
3.1.3
3.1.7.3
monoterpenyl-diphosphatase
|
–
–
|
|
KEGG:
R08529
MetaCyc:
RXN-13046
|
|
|
|
geranyl_diphosphate + H2O <=> (-)-endo-fenchol + diphosphate
|
4.2.3.10
(-)-endo-fenchol synthase
|
–
|
|
BRENDA:
BR48348;
BS430215
KEGG:
R02004
MetaCyc:
4.2.3.10-RXN
|
|
|
|
7-deoxyloganate + reduced_flavodoxin + O2 <=> loganic_acid + flavin + H2O
|
1.14.14.85
7-deoxyloganate 7-hydroxylase
|
–
|
|
BRENDA:
BR40528
KEGG:
R05832
|
|
|
|
(6E)-8-hydroxygeraniol + NADP+ <=> (6E)-8-oxogeranial + NADPH + H+
|
1.1.1.324
8-hydroxygeraniol dehydrogenase
|
–
|
|
BRENDA:
BR50014
KEGG:
R08499
MetaCyc:
RXN-12961
|
|
|
|
geranyl_diphosphate + H2O <=> geraniol + diphosphate
|
3.1.7.11
geranyl diphosphate diphosphatase
3.1.7.3
monoterpenyl-diphosphatase
4.2.3.104
alpha-humulene synthase
|
–
–
–
|
|
BRENDA:
BR50059
KEGG:
R08396
MetaCyc:
RXN-17103;
RXN-8618
SABIO-RK:
12967
|
|
|
|
loganin + reduced_flavodoxin + O2 <=> secologanin + flavin + 2 H2O
|
1.14.19.62
secologanin synthase
|
–
|
|
BRENDA:
BR40360
KEGG:
R03555
|
|
|
|
(-)-trans-isopiperitenol + NAD+ <=> (-)-isopiperitenone + NADH + H+
|
1.1.1.223
isopiperitenol dehydrogenase
|
–
|
|
BRENDA:
BR29264
KEGG:
R03261
MetaCyc:
ISOPIPERITENOL-DEHYDROGENASE-RXN
|
|
|
|
loganic_acid <=> 10-Deoxygeniposidic_acid
|
not assigned
|
–
|
|
KEGG:
R05898
|
|
|
|
geranyl_diphosphate + H2O <=> (3R)-linalool + diphosphate
|
4.2.3.25
S-linalool synthase
4.2.3.26
R-linalool synthase
|
–
–
|
|
BRENDA:
BR48698;
BS398886
KEGG:
R07632
MetaCyc:
4.2.3.26-RXN
|
|
|
|
geranyl_diphosphate + H2O <=> Sabinene_hydrate + diphosphate
|
4.2.3.11
sabinene-hydrate synthase
|
–
|
|
BRENDA:
BR48349
KEGG:
R02006
MetaCyc:
4.2.3.11-RXN
|
|
|
|
1,8-cineole + reduced_flavodoxin + O2 <=> 6-endo-hydroxycineole + flavin + H2O
|
1.14.14.133
1,8-cineole 2-endo-monooxygenase
|
–
|
|
KEGG:
R08784
MetaCyc:
RXN-13136
|
|
|
|
geraniol <=> (3S)-linalool
|
5.4.4.4
geraniol isomerase
5.4.4.8
linalool isomerase
|
–
–
|
|
BRENDA:
BR49509
KEGG:
R09708
MetaCyc:
RXN-12336
|
|
|
|
UDP-glucose + 7-deoxyloganetin <=> UDP + 7-deoxyloganin + H+
|
2.4.1.324
7-deoxyloganetin glucosyltransferase
|
–
|
|
BRENDA:
BR50954
KEGG:
R10835
MetaCyc:
RXN-15236
|
|
|
|
geranyl_diphosphate <=> (-)-camphene + diphosphate
|
4.2.3
4.2.3.116
(+)-camphene synthase
4.2.3.117
(-)-camphene synthase
|
–
–
–
|
|
BRENDA:
BR50080
KEGG:
R02011;
R09972
MetaCyc:
RXN-5142
|
|
|
|
(+)-borneol + NAD+ <=> (+)-Camphor + NADH + H+
|
1.1.1.198
(+)-borneol dehydrogenase
|
–
|
|
BRENDA:
BR29247
KEGG:
R02944
MetaCyc:
+-BORNEOL-DEHYDROGENASE-RXN
|
|
|
|
(-)-limonene + reduced_flavodoxin + O2 <=> (-)-trans-isopiperitenol + flavin + H2O
|
1.14.14.99
(S)-limonene 3-monooxygenase
|
–
|
|
BRENDA:
BR36763
KEGG:
R02469
|
|
|
|
(4R)-ipsdienol + NAD+ <=> ipsdienone + NADH + H+
|
1.1.1.386
ipsdienol dehydrogenase
|
–
|
|
BRENDA:
BR51210-a
KEGG:
R10918
MetaCyc:
RXN-15051_WOP
|
|
|
|
geranyl_diphosphate + H2O <=> (-)-alpha-terpineol + diphosphate
|
4.2.3.108
1,8-cineole synthase
4.2.3.111
(-)-alpha-terpineol synthase
4.2.3.112
(+)-alpha-terpineol synthase
|
–
–
–
|
|
BRENDA:
BR50074;
BS444324
KEGG:
R06421
MetaCyc:
RXN-5101
|
|
|
|
(S)-8-oxocitronellyl_enol + NAD+ <=> (6E)-8-oxogeranial + NADH + H+
|
1.3.1.122
(S)-8-oxocitronellyl enol synthase
|
–
|
|
BRENDA:
BR52966-a
KEGG:
R12517
MetaCyc:
RXN-20745_WOP
|
|
|
|
(3S)-linalool + reduced_flavodoxin + O2 <=> (6E)-8-hydroxylinalool + flavin + H2O
|
1.14.14.84
linalool 8-monooxygenase
|
–
|
|
KEGG:
R09922
|
|
|
|
geranyl_diphosphate <=> (+)-limonene + diphosphate
|
4.2.3.20
(R)-limonene synthase
|
–
|
|
BRENDA:
BR47586
KEGG:
R06120
MetaCyc:
4.2.3.20-RXN
|
|
|
|
(+)-cis-isopulegone + NADP+ <=> (-)-isopiperitenone + NADPH + H+
|
1.3.1.82
(-)-isopiperitenone reductase
|
–
|
|
BRENDA:
BR48928
KEGG:
R06417
MetaCyc:
RXN-5161
|
|
|
|
(S)-8-oxocitronellyl_enol + NADP+ <=> (6E)-8-oxogeranial + NADPH + H+
|
1.3.1.122
(S)-8-oxocitronellyl enol synthase
|
–
|
|
BRENDA:
BR52966
KEGG:
R12518
MetaCyc:
RXN-20745
|
|
|
|
(6E)-8-hydroxylinalool + reduced_flavodoxin + O2 <=> (6E)-8-oxolinalool + flavin + 2 H2O
|
1.14.14.84
linalool 8-monooxygenase
|
–
|
|
BRENDA:
BR50025
KEGG:
R09924
|
|
|
|
Geniposidic_acid <=> asperuloside
|
not assigned
|
–
|
|
KEGG:
R05900
|
|
|
|
(+)-trans-carveol + NAD+ <=> (S)-carvone + NADH + H+
|
1.1.1.275
(+)-trans-carveol dehydrogenase
|
–
|
|
BRENDA:
BR47616
KEGG:
R06117
MetaCyc:
RXN-9397
|
|
|
|
S-adenosyl-L-methionine + loganic_acid <=> S-adenosyl-L-homocysteine + loganin
|
2.1.1.50
loganate O-methyltransferase
|
–
|
|
BRENDA:
BR40557
KEGG:
R03554
MetaCyc:
LOGANATE-O-METHYLTRANSFERASE-RXN
|
|
|
|
(-)-menthone + NADPH + H+ + O2 <=> (4R,7S)-7-isopropyl-4-methyloxepan-2-one + NADP+ + H2O
|
1.14.13.105
monocyclic monoterpene ketone monooxygenase
|
–
|
|
BRENDA:
BR48904
KEGG:
R08925
MetaCyc:
RXN-9441
SABIO-RK:
12386
|
|
|
|
NADP+ + (-)-menthol <=> H+ + (-)-menthone + NADPH
|
1.1.1.207
(-)-menthol dehydrogenase
|
–
|
|
BRENDA:
BR33668
KEGG:
R02177
MetaCyc:
--MENTHOL-DEHYDROGENASE-RXN
SABIO-RK:
2150
|
|
|
|
(+)-limonene + reduced_flavodoxin + O2 <=> (+)-trans-carveol + flavin + H2O
|
1.14.14.53
(R)-limonene 6-monooxygenase
|
–
|
|
BRENDA:
BR47606
KEGG:
R06119
|
|
|
|
(-)-alpha-terpineol <=> 1,8-cineole
|
4.2.3.108
1,8-cineole synthase
|
–
|
|
KEGG:
R06422
|
|
|
|
(R)-pulegone + reduced_flavodoxin + O2 <=> (+)-menthofuran + flavin + H2O
|
1.14.14.143
(+)-menthofuran synthase
|
–
|
|
BRENDA:
BR48926
KEGG:
R08923
|
|
|
|
(3S)-linalool <=> myrcene + H2O
|
4.2.1.127
linalool dehydratase
|
–
|
|
BRENDA:
BR49504
KEGG:
R09702
MetaCyc:
RXN-12335
|
|
|
|
(-)-trans-carveol + NADP+ <=> (-)-Carvone + NADPH + H+
|
1.1.1.243
carveol dehydrogenase
1.3.1.102
2-alkenal reductase (NADP+)
|
–
–
|
|
BRENDA:
BR29279
KEGG:
R03114
MetaCyc:
CARVEOL-DEHYDROGENASE-RXN
SABIO-RK:
2951
|
|
|
|
geranyl_diphosphate <=> (+)-camphene + diphosphate
|
4.2.3.116
(+)-camphene synthase
4.2.3.20
(R)-limonene synthase
|
–
–
|
|
BRENDA:
BR50079
KEGG:
R09971
MetaCyc:
RXN-8576
|
|
|
|
10-Deoxygeniposidic_acid <=> Geniposidic_acid
|
not assigned
|
–
|
|
KEGG:
R05899
|
|
|
|
geranyl_diphosphate <=> (-)-beta-pinene + diphosphate
|
4.2.3.120
(-)-beta-pinene synthase
4.2.3.122
(+)-beta-pinene synthase
|
–
–
|
|
BRENDA:
BR50083
KEGG:
R05766
MetaCyc:
RXN-5107
|
|
|
|
myrcene + reduced_flavodoxin + O2 <=> (4R)-ipsdienol + flavin + H2O
|
1.14.14.31
ipsdienol synthase
|
–
|
|
BRENDA:
BR51495
KEGG:
R11055
|
|
|
|
7-deoxyloganetic_alcohol + reduced_flavodoxin + O2 <=> iridotrial + flavin + 2 H2O
|
1.14.14.161
nepetalactol monooxygenase
|
–
|
|
BRENDA:
BR52521
KEGG:
R12253
|
|
|
|
S-adenosyl-L-methionine + secologanate <=> S-adenosyl-L-homocysteine + secologanin
|
2.1.1.50
loganate O-methyltransferase
|
–
|
|
BRENDA:
BS289542
KEGG:
R05834
MetaCyc:
RXN-4523
|
|
|
|
geranyl_diphosphate <=> (+)-bornyl-diphosphate
|
5.5.1.8
(+)-bornyl diphosphate synthase
|
–
|
|
BRENDA:
BR266
KEGG:
R02007
MetaCyc:
GERANYL-DIPHOSPHATE-CYCLASE-RXN
|
|
|
|
iridotrial <=> 7-deoxyloganetin
|
not assigned
|
–
|
|
KEGG:
R05090
|
|
|
|
(+)-cis-isopulegone <=> (R)-pulegone
|
5.3.3
|
–
|
|
KEGG:
R06418
MetaCyc:
RXN-5162
|
|
|
|
geranyl_diphosphate <=> myrcene + diphosphate
|
4.2.3.15
myrcene synthase
4.2.3.20
(R)-limonene synthase
|
–
–
|
|
BRENDA:
BR22830
KEGG:
R02009
MetaCyc:
RXN-5110
|
|
|
|
(-)-menthone + NADP+ <=> (R)-pulegone + NADPH + H+
|
1.3.1.81
(+)-pulegone reductase
|
–
|
|
BRENDA:
BR48922
KEGG:
R06419
MetaCyc:
RXN-5163
|
|
|
|
linalool + reduced_flavodoxin + O2 <=> (6E)-8-hydroxylinalool + flavin + H2O
|
1.14.14.84
linalool 8-monooxygenase
|
–
|
|
BRENDA:
BR50024
KEGG:
R04366;
R09923
|
|
|
|
geranyl_diphosphate + H2O <=> (3S)-linalool + diphosphate
|
4.2.3.25
S-linalool synthase
4.2.3.48
(3S,6E)-nerolidol synthase
|
–
–
|
|
BRENDA:
BR48697
KEGG:
R07631
MetaCyc:
4.2.3.25-RXN
SABIO-RK:
14621
|
|
|
|
geraniol + reduced_flavodoxin + O2 <=> (6E)-8-hydroxygeraniol + flavin + H2O
|
1.14.14.1
unspecific monooxygenase
1.14.14.83
geraniol 8-hydroxylase
|
–
–
|
|
BRENDA:
BR50026
KEGG:
R08785
|
|
|
|
iridotrial + reduced_flavodoxin + O2 <=> 7-deoxyloganetate + flavin + H2O
|
1.14.14.161
nepetalactol monooxygenase
|
–
|
|
BRENDA:
BR52522
KEGG:
R12182
|
|
|
|
1,6,6-Trimethyl-2,7-dioxa(3,2,2)bicyclononan-3-one <=> 4,5-Dihydro-5,5-dimethyl-4-(3-oxobutyl)furan-2(3H)-one
|
not assigned
|
–
|
|
KEGG:
R04578
MetaCyc:
C04718-C060066-AUTOTRANSFORMATION-RXN
|
|
|
|
2-exo-hydroxy-1,8-cineole + NAD+ <=> 6-Oxocineole + NADH + H+
|
1.1.1.241
6-endo-hydroxycineole dehydrogenase
|
–
|
|
BRENDA:
BR29278
KEGG:
R02994
MetaCyc:
6-ENDO-HYDROXYCINEOLE-DEHYDROGENASE-RXN
|
|
|
|
6-Oxocineole + O2 + NADPH + H+ <=> 1,6,6-Trimethyl-2,7-dioxa(3,2,2)bicyclononan-3-one + H2O + NADP+
|
1.14.13.51
6-oxocineole dehydrogenase
|
–
|
|
BRENDA:
BR40414
KEGG:
R02995
MetaCyc:
6-OXOCINEOLE-DEHYDROGENASE-RXN
|
|
|
|
7-deoxyloganin + reduced_flavodoxin + O2 <=> loganin + flavin + H2O
|
1.14.14.85
7-deoxyloganate 7-hydroxylase
|
–
|
|
BRENDA:
BS289300
KEGG:
R03556
|
|
|
|
(S)-8-oxocitronellyl_enol <=> cis-trans-nepetalactol
|
5.5.1.34
(+)-cis,trans-nepetalactol synthase
|
–
|
|
BRENDA:
BR52967
KEGG:
R12520
MetaCyc:
RXN-20744
|
|
|
|
geranyl_diphosphate + H2O <=> geranyl_phosphate + phosphate + H+
|
3.6.1.68
geranyl diphosphate phosphohydrolase
|
–
|
|
BRENDA:
BR51531
KEGG:
R11551
MetaCyc:
RXN-17104
|
|
|
|
geranyl_diphosphate <=> (-)-limonene + diphosphate
|
4.2.3.101
7-epi-sesquithujene synthase
4.2.3.102
sesquithujene synthase
4.2.3.118
2-methylisoborneol synthase
4.2.3.16
(4S)-limonene synthase
|
–
–
–
–
|
|
BRENDA:
BR22831;
BS398891
KEGG:
R02013
MetaCyc:
4.2.3.16-RXN
|
|
|
|
(-)-limonene + reduced_flavodoxin + O2 <=> (S)-perillyl_alcohol + flavin + H2O
|
1.14.14.52
(S)-limonene 7-monooxygenase
|
–
|
|
BRENDA:
BR36765
KEGG:
R02470
|
|
|
|
(+)-isomenthone + NADP+ <=> (R)-pulegone + NADPH + H+
|
1.3.1.81
(+)-pulegone reductase
|
–
|
|
BRENDA:
BR48923
KEGG:
R06420
MetaCyc:
RXN-5164
|
|
|
|
UDP-glucose + 7-deoxyloganetate <=> H+ + 7-deoxyloganate + UDP
|
2.4.1.323
7-deoxyloganetic acid glucosyltransferase
|
–
|
|
BRENDA:
BR50953
KEGG:
R10834
MetaCyc:
RXN-9372
|
|
|
|
(-)-limonene + reduced_flavodoxin + O2 <=> (-)-trans-carveol + flavin + H2O
|
1.14.14.51
(S)-limonene 6-monooxygenase
|
–
|
|
BRENDA:
BR36764
KEGG:
R02468
|
|
|
|
loganic_acid + reduced_flavodoxin + O2 <=> secologanate + flavin + 2 H2O
|
1.14.19.62
secologanin synthase
|
–
|
|
KEGG:
R05833
|
|
|
|
(4R)-ipsdienol + NADP+ <=> ipsdienone + NADPH + H+
|
1.1.1.386
ipsdienol dehydrogenase
|
–
|
|
BRENDA:
BR51210
KEGG:
R10919
MetaCyc:
RXN-15051
SABIO-RK:
14711
|
|
|
|
geranyl_diphosphate <=> (-)-alpha-pinene + diphosphate
|
4.2.3.119
(-)-alpha-pinene synthase
4.2.3.121
(+)-alpha-pinene synthase
|
–
–
|
|
BRENDA:
BR50082
KEGG:
R05765
MetaCyc:
RXN-5106
|
|
|
|
cis-trans-nepetalactol + reduced_flavodoxin + O2 <=> 7-deoxyloganetic_alcohol + flavin + H2O
|
1.14.14.161
nepetalactol monooxygenase
|
–
|
|
BRENDA:
BR52520
KEGG:
R12231
|
|
|
|
NADP+ + (+)-neomenthol <=> H+ + NADPH + (-)-menthone
|
1.1.1.208
(+)-neomenthol dehydrogenase
|
–
|
|
BRENDA:
BR33669
KEGG:
R02548
MetaCyc:
+-NEOMENTHOL-DEHYDROGENASE-RXN
SABIO-RK:
2463
|
|
|
|
geranyl_phosphate + H2O <=> geraniol + phosphate
|
3.1.3
3.1.3.76
lipid-phosphate phosphatase
3.1.7.1
prenyl-diphosphatase
|
–
–
–
|
|
BRENDA:
BS379794
KEGG:
R11552
MetaCyc:
RXN-17102
|
|