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Monoterpenoid biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
(+)-bornyl-diphosphate + H2O <=> (+)-borneol + diphosphate 3.1.3
3.1.7.3 monoterpenyl-diphosphatase


geranyl_diphosphate + H2O <=> (-)-endo-fenchol + diphosphate 4.2.3.10 (-)-endo-fenchol synthase

7-deoxyloganate + reduced_flavodoxin + O2 <=> loganic_acid + flavin + H2O 1.14.14.85 7-deoxyloganate 7-hydroxylase

(6E)-8-hydroxygeraniol + NADP+ <=> (6E)-8-oxogeranial + NADPH + H+ 1.1.1.324 8-hydroxygeraniol dehydrogenase

geranyl_diphosphate + H2O <=> geraniol + diphosphate 3.1.7.11 geranyl diphosphate diphosphatase
3.1.7.3 monoterpenyl-diphosphatase
4.2.3.104 alpha-humulene synthase



loganin + reduced_flavodoxin + O2 <=> secologanin + flavin + 2 H2O 1.14.19.62 secologanin synthase

(-)-trans-isopiperitenol + NAD+ <=> (-)-isopiperitenone + NADH + H+ 1.1.1.223 isopiperitenol dehydrogenase

loganic_acid <=> 10-Deoxygeniposidic_acid not assigned

geranyl_diphosphate + H2O <=> (3R)-linalool + diphosphate 4.2.3.25 S-linalool synthase
4.2.3.26 R-linalool synthase


geranyl_diphosphate + H2O <=> Sabinene_hydrate + diphosphate 4.2.3.11 sabinene-hydrate synthase

1,8-cineole + reduced_flavodoxin + O2 <=> 6-endo-hydroxycineole + flavin + H2O 1.14.14.133 1,8-cineole 2-endo-monooxygenase

geraniol <=> (3S)-linalool 5.4.4.4 geraniol isomerase
5.4.4.8 linalool isomerase


UDP-glucose + 7-deoxyloganetin <=> UDP + 7-deoxyloganin + H+ 2.4.1.324 7-deoxyloganetin glucosyltransferase

geranyl_diphosphate <=> (-)-camphene + diphosphate 4.2.3
4.2.3.116 (+)-camphene synthase
4.2.3.117 (-)-camphene synthase



(+)-borneol + NAD+ <=> (+)-Camphor + NADH + H+ 1.1.1.198 (+)-borneol dehydrogenase

(-)-limonene + reduced_flavodoxin + O2 <=> (-)-trans-isopiperitenol + flavin + H2O 1.14.14.99 (S)-limonene 3-monooxygenase

(4R)-ipsdienol + NAD+ <=> ipsdienone + NADH + H+ 1.1.1.386 ipsdienol dehydrogenase

geranyl_diphosphate + H2O <=> (-)-alpha-terpineol + diphosphate 4.2.3.108 1,8-cineole synthase
4.2.3.111 (-)-alpha-terpineol synthase
4.2.3.112 (+)-alpha-terpineol synthase



(S)-8-oxocitronellyl_enol + NAD+ <=> (6E)-8-oxogeranial + NADH + H+ 1.3.1.122 (S)-8-oxocitronellyl enol synthase

(3S)-linalool + reduced_flavodoxin + O2 <=> (6E)-8-hydroxylinalool + flavin + H2O 1.14.14.84 linalool 8-monooxygenase

geranyl_diphosphate <=> (+)-limonene + diphosphate 4.2.3.20 (R)-limonene synthase

(+)-cis-isopulegone + NADP+ <=> (-)-isopiperitenone + NADPH + H+ 1.3.1.82 (-)-isopiperitenone reductase

(S)-8-oxocitronellyl_enol + NADP+ <=> (6E)-8-oxogeranial + NADPH + H+ 1.3.1.122 (S)-8-oxocitronellyl enol synthase

(6E)-8-hydroxylinalool + reduced_flavodoxin + O2 <=> (6E)-8-oxolinalool + flavin + 2 H2O 1.14.14.84 linalool 8-monooxygenase

Geniposidic_acid <=> asperuloside not assigned

(+)-trans-carveol + NAD+ <=> (S)-carvone + NADH + H+ 1.1.1.275 (+)-trans-carveol dehydrogenase

S-adenosyl-L-methionine + loganic_acid <=> S-adenosyl-L-homocysteine + loganin 2.1.1.50 loganate O-methyltransferase

(-)-menthone + NADPH + H+ + O2 <=> (4R,7S)-7-isopropyl-4-methyloxepan-2-one + NADP+ + H2O 1.14.13.105 monocyclic monoterpene ketone monooxygenase

NADP+ + (-)-menthol <=> H+ + (-)-menthone + NADPH 1.1.1.207 (-)-menthol dehydrogenase

(+)-limonene + reduced_flavodoxin + O2 <=> (+)-trans-carveol + flavin + H2O 1.14.14.53 (R)-limonene 6-monooxygenase

(-)-alpha-terpineol <=> 1,8-cineole 4.2.3.108 1,8-cineole synthase

(R)-pulegone + reduced_flavodoxin + O2 <=> (+)-menthofuran + flavin + H2O 1.14.14.143 (+)-menthofuran synthase

(3S)-linalool <=> myrcene + H2O 4.2.1.127 linalool dehydratase

(-)-trans-carveol + NADP+ <=> (-)-Carvone + NADPH + H+ 1.1.1.243 carveol dehydrogenase
1.3.1.102 2-alkenal reductase (NADP+)


geranyl_diphosphate <=> (+)-camphene + diphosphate 4.2.3.116 (+)-camphene synthase
4.2.3.20 (R)-limonene synthase


10-Deoxygeniposidic_acid <=> Geniposidic_acid not assigned

geranyl_diphosphate <=> (-)-beta-pinene + diphosphate 4.2.3.120 (-)-beta-pinene synthase
4.2.3.122 (+)-beta-pinene synthase


myrcene + reduced_flavodoxin + O2 <=> (4R)-ipsdienol + flavin + H2O 1.14.14.31 ipsdienol synthase

7-deoxyloganetic_alcohol + reduced_flavodoxin + O2 <=> iridotrial + flavin + 2 H2O 1.14.14.161 nepetalactol monooxygenase

S-adenosyl-L-methionine + secologanate <=> S-adenosyl-L-homocysteine + secologanin 2.1.1.50 loganate O-methyltransferase

geranyl_diphosphate <=> (+)-bornyl-diphosphate 5.5.1.8 (+)-bornyl diphosphate synthase

iridotrial <=> 7-deoxyloganetin not assigned

(+)-cis-isopulegone <=> (R)-pulegone 5.3.3

geranyl_diphosphate <=> myrcene + diphosphate 4.2.3.15 myrcene synthase
4.2.3.20 (R)-limonene synthase


(-)-menthone + NADP+ <=> (R)-pulegone + NADPH + H+ 1.3.1.81 (+)-pulegone reductase

linalool + reduced_flavodoxin + O2 <=> (6E)-8-hydroxylinalool + flavin + H2O 1.14.14.84 linalool 8-monooxygenase

geranyl_diphosphate + H2O <=> (3S)-linalool + diphosphate 4.2.3.25 S-linalool synthase
4.2.3.48 (3S,6E)-nerolidol synthase


geraniol + reduced_flavodoxin + O2 <=> (6E)-8-hydroxygeraniol + flavin + H2O 1.14.14.1 unspecific monooxygenase
1.14.14.83 geraniol 8-hydroxylase


iridotrial + reduced_flavodoxin + O2 <=> 7-deoxyloganetate + flavin + H2O 1.14.14.161 nepetalactol monooxygenase

1,6,6-Trimethyl-2,7-dioxa(3,2,2)bicyclononan-3-one <=> 4,5-Dihydro-5,5-dimethyl-4-(3-oxobutyl)furan-2(3H)-one not assigned

2-exo-hydroxy-1,8-cineole + NAD+ <=> 6-Oxocineole + NADH + H+ 1.1.1.241 6-endo-hydroxycineole dehydrogenase

6-Oxocineole + O2 + NADPH + H+ <=> 1,6,6-Trimethyl-2,7-dioxa(3,2,2)bicyclononan-3-one + H2O + NADP+ 1.14.13.51 6-oxocineole dehydrogenase

7-deoxyloganin + reduced_flavodoxin + O2 <=> loganin + flavin + H2O 1.14.14.85 7-deoxyloganate 7-hydroxylase

(S)-8-oxocitronellyl_enol <=> cis-trans-nepetalactol 5.5.1.34 (+)-cis,trans-nepetalactol synthase

geranyl_diphosphate + H2O <=> geranyl_phosphate + phosphate + H+ 3.6.1.68 geranyl diphosphate phosphohydrolase

geranyl_diphosphate <=> (-)-limonene + diphosphate 4.2.3.101 7-epi-sesquithujene synthase
4.2.3.102 sesquithujene synthase
4.2.3.118 2-methylisoborneol synthase
4.2.3.16 (4S)-limonene synthase




(-)-limonene + reduced_flavodoxin + O2 <=> (S)-perillyl_alcohol + flavin + H2O 1.14.14.52 (S)-limonene 7-monooxygenase

(+)-isomenthone + NADP+ <=> (R)-pulegone + NADPH + H+ 1.3.1.81 (+)-pulegone reductase

UDP-glucose + 7-deoxyloganetate <=> H+ + 7-deoxyloganate + UDP 2.4.1.323 7-deoxyloganetic acid glucosyltransferase

(-)-limonene + reduced_flavodoxin + O2 <=> (-)-trans-carveol + flavin + H2O 1.14.14.51 (S)-limonene 6-monooxygenase

loganic_acid + reduced_flavodoxin + O2 <=> secologanate + flavin + 2 H2O 1.14.19.62 secologanin synthase

(4R)-ipsdienol + NADP+ <=> ipsdienone + NADPH + H+ 1.1.1.386 ipsdienol dehydrogenase

geranyl_diphosphate <=> (-)-alpha-pinene + diphosphate 4.2.3.119 (-)-alpha-pinene synthase
4.2.3.121 (+)-alpha-pinene synthase


cis-trans-nepetalactol + reduced_flavodoxin + O2 <=> 7-deoxyloganetic_alcohol + flavin + H2O 1.14.14.161 nepetalactol monooxygenase

NADP+ + (+)-neomenthol <=> H+ + NADPH + (-)-menthone 1.1.1.208 (+)-neomenthol dehydrogenase

geranyl_phosphate + H2O <=> geraniol + phosphate 3.1.3
3.1.3.76 lipid-phosphate phosphatase
3.1.7.1 prenyl-diphosphatase



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